DETAILED NOTES ON LDN-27219 CHEMICAL STRUCTURE

One especially fascinating compound is LDN-27219. While most tTG inhibitors are meant to bind to your protein crosslinking active web site, LDN-27219 alternatively binds towards the nucleotide binding pocket of the enzyme when it truly is in its shut-condition conformation, and stabilizes that conformation to stop crosslinking activity.78 Schneider